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Find clinical trials for Melanoma in Birmingham, AL

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Squamous Cell Carcinoma

Melanoma trials near Birmingham, AL, USA:

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who ...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

Phase 3

Iovance Biotherapeutics

Birmingham, Alabama, United States and 47 other locations

efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma...

Enrolling
Ocular Melanoma
Choroidal Melanoma
Device: Suprachoroidal Microinjector
Drug: Bel-sar

Phase 3

Aura Biosciences
Aura Biosciences

Birmingham, Alabama, United States and 49 other locations

of ANV419 with anti-PD1 antibody or with anti-CTLA4 antibody in adult participants with advanced (unresectable or metastatic) cutaneous melanoma...

Enrolling
Melanoma (Skin)
Metastatic Melanoma
Drug: Ipilimumab
Drug: Pembrolizumab

Phase 1, Phase 2

Anaveon

Birmingham, Alabama, United States and 24 other locations

to assess nivolumab plus relatlimab fixed-dose combination (FDC) versus nivolumab alone in participants with completely resected stage III-IV melanoma...

Active, not recruiting
Melanoma
Biological: Nivolumab
Biological: Nivolumab + Relatlimab Fixed Dose Combination

Phase 3

Bristol-Myers Squibb (BMS)
Bristol-Myers Squibb (BMS)

Birmingham, Alabama, United States and 171 other locations

and pediatric participants after complete resection of Stage IIB/C melanoma with no evidence of disease (NED) who are at high risk for recur...

Active, not recruiting
Melanoma
Other: Placebo
Biological: Nivolumab

Phase 3

Bristol-Myers Squibb (BMS)
Bristol-Myers Squibb (BMS)

Birmingham, Alabama, United States and 128 other locations

RPL-001-16 is a Phase 1/2, open label, dose escalation and expansion clinical study of RP1 alone and in combination with nivolumab in adult subjects...

Enrolling
Non-melanoma Skin Cancer
Melanoma (Skin)
Biological: RP1
Biological: nivolumab

Phase 2

Replimune

Birmingham, Alabama, United States and 52 other locations

The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected...

Enrolling
Advanced Unresectable Solid Tumor
Metastatic Solid Tumor
Drug: Toripalimab
Drug: TAB004

Phase 1

TopAlliance Biosciences

Birmingham, Alabama, United States and 23 other locations

This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immuno...

Enrolling
Melanoma, Malignant
Ovarian Carcinoma
Biological: NM32-2668

Phase 1

Numab Therapeutics

Birmingham, Alabama, United States and 7 other locations

To evaluate the efficacy of naporafenib administered with trametinib in patients with rat sarcoma viral oncogene (RAS) Q61X solid tumors* To evaluate...

Enrolling
Advanced or Metastatic Solid Tumors
Drug: Trametinib
Drug: Naporafenib

Phase 1

Erasca

Birmingham, Alabama, United States and 30 other locations

This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also s...

Enrolling
Melanoma
Ovarian Neoplasms
Drug: pembrolizumab
Drug: PF-08046054

Phase 1

Seagen
Seagen

Birmingham, Alabama, United States and 23 other locations

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