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Find clinical trials for Melanoma in Louisville, KY

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Carcinoma
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Non-Small-Cell Lung Carcinoma
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Squamous Cell Carcinoma

Melanoma trials near Louisville, KY, USA:

Nemvaleukin Alfa (ALKS 4230) Monotherapy in Patients With Advanced Cutaneous Melanoma or Advanced Mucosal Melanoma - ARTISTRY-6

This study observes the antitumor activity, safety, tolerability, PK, and pharmacodynamics in patients with inoperable and/or metastatic melanoma...

Enrolling
Mucosal Melanoma
Cutaneous Melanoma
Drug: Nemvaleukin Alfa Intravenous Less Frequent Dosing
Drug: Nemvaleukin Alfa Intravenous

Phase 2

Mural Oncology

Louisville, Kentucky, United States and 40 other locations

alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who ...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

Phase 3

Iovance Biotherapeutics

Louisville, Kentucky, United States and 32 other locations

Prospective, interventional multicenter study evaluating adoptive cell therapy (ACT) via infusion of LN-144 (autologous TIL) followed by interleukin...

Active, not recruiting
Metastatic Melanoma
Biological: Lifileucel

Phase 2

Iovance Biotherapeutics

Louisville, Kentucky, United States of America and 56 other locations

administered to participants with unresectable or metastatic melanoma.The study is divided into two phases: Phase 2 and Phase 3.The primary ...

Active, not recruiting
Advanced Melanoma
Melanoma
Drug: Nivolumab
Drug: CMP-001

Phase 2, Phase 3

Regeneron Pharmaceuticals
Regeneron Pharmaceuticals

Louisville, Kentucky, United States and 19 other locations

This is a study to investigate the efficacy and safety of an infusion of IOV-4001 in adult participants with unresectable or metastatic melanoma...

Enrolling
Metastatic Melanoma
Unresectable Melanoma
Biological: IOV-4001

Phase 1, Phase 2

Iovance Biotherapeutics

Louisville, Kentucky, United States and 7 other locations

RPL-001-16 is a Phase 1/2, open label, dose escalation and expansion clinical study of RP1 alone and in combination with nivolumab in adult subjects...

Enrolling
Non-melanoma Skin Cancer
Melanoma (Skin)
Biological: RP1
Biological: nivolumab

Phase 2

Replimune

Louisville, Kentucky, United States and 52 other locations

The objective of this study is to assess safety and efficacy of CAB-ROR2-ADC in solid tumors

Enrolling
Melanoma
Non Small Cell Lung Cancer
Biological: PD-1 inhibitor
Biological: CAB-ROR2-ADC

Phase 1, Phase 2

BioAtla

Louisville, Kentucky, United States and 65 other locations

This is a study to investigate the safety and efficacy of an investigational OBX-115 regimen in adult participants with advanced solid tumors.

Enrolling
Melanoma
Metastatic Melanoma
Biological: OBX-115

Phase 1, Phase 2

Obsidian Therapeutics

Louisville, Kentucky, United States of America and 5 other locations

A multicenter trial to investigate TBio-4101, an autologous, neoantigen-selected, tumor-reactive TIL product, in patients with advanced solid maligna...

Enrolling
Cutaneous Melanoma
Uveal Melanoma
Biological: TBio-4101
Drug: Pembrolizumab

Phase 1

Turnstone Biologics

Louisville, Kentucky, United States and 9 other locations

This is a Phase 1/2, open-label, non-randomized, 4-part Phase 1 trial to determine the safety profile and identify the maximum tolerated dose (MTD) a...

Enrolling
Melanoma
Solid Tumor
Drug: Pembrolizumab 400 mg
Drug: INBRX-106 - Hexavalent OX40 agonist antibody

Phase 1

Inhibrx

Louisville, Kentucky, United States and 16 other locations

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