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Find clinical trials for Melanoma in Philadelphia, PA

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Melanoma trials near Philadelphia, PA, USA:

(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma

Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma...

Enrolling
Uveal Melanoma
Drug: Darovasertib

Phase 2

Ideaya Biosciences

Philadelphia, Pennsylvania, United States and 22 other locations

alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who ...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

Phase 3

Iovance Biotherapeutics

Camden, New Jersey, United States of America and 32 other locations

therapy per local standard of care (SoC), best supportive care (BSC)) on protocol survivor follow up) in patients with advanced non-ocular melanoma...

Enrolling
Advanced Melanoma
Drug: Tebentafusp with Pembrolizumab
Drug: Tebentafusp

Phase 2, Phase 3

Immunocore
Immunocore

Philadelphia, Pennsylvania, United States and 70 other locations

of using hydroxychloroquine (HCQ) in combination with nivolumab and ipilimumab or with nivolumab alone in subjects with advanced/metastatic melanoma...

Enrolling
Melanoma
Drug: Nivolumab
Drug: Hydroxychloroquine

Phase 1, Phase 2

Ravi Amaravadi, MD

Philadelphia, Pennsylvania, United States

safety, tolerability, and preliminary efficacy of belzupacap sarotalocan for the treatment of primary indeterminate lesions and small choroidal melanoma...

Active, not recruiting
Ocular Melanoma
Choroidal Melanoma
Device: Suprachoroidal Microinjector
Device: PDT Laser

Phase 2

Aura Biosciences
Aura Biosciences

Philadelphia, Pennsylvania, United States and 21 other locations

emitting therapeutic agent targeted to melanocortin sub-type 1 receptor (MC1R) is being evaluated in patients with unresectable and metastatic melanoma...

Enrolling
Mucosal Melanoma
Melanoma Stage IV
Drug: [203Pb]VMT01
Drug: [212Pb]VMT01

Phase 1, Phase 2

Perspective Therapeutics

Philadelphia, Pennsylvania, United States of America and 8 other locations

This phase II trial studies how well nivolumab works in treating patients with stage IIB-IIC melanoma that can be removed by surgery. Monocl...

Active, not recruiting
Melanoma (Skin)
Biological: Nivolumab

Phase 2

Sidney Kimmel Cancer Center at Thomas Jefferson University

Philadelphia, Pennsylvania, United States and 3 other locations

efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma...

Enrolling
Ocular Melanoma
Choroidal Melanoma
Device: Suprachoroidal Microinjector
Drug: Sham Treatment

Phase 3

Aura Biosciences
Aura Biosciences

Philadelphia, Pennsylvania, United States and 37 other locations

This randomized phase II trial studies how well sunitinib malate or valproic acid works in preventing high-risk uveal (eye) melanoma from sp...

Active, not recruiting
Stage IIB Intraocular Melanoma
Stage I Intraocular Melanoma
Drug: Sunitinib
Drug: Valproic Acid

Phase 2

Sidney Kimmel Cancer Center at Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Prospective, interventional multicenter study evaluating adoptive cell therapy (ACT) via infusion of LN-144 (autologous TIL) followed by interleukin...

Active, not recruiting
Metastatic Melanoma
Biological: Lifileucel

Phase 2

Iovance Biotherapeutics

Philadelphia, Pennsylvania, United States and 56 other locations

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