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Find clinical trials for Melanoma in Pittsburgh, PA

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Uveal Melanoma

Melanoma trials near Pittsburgh, PA, USA:

Neoadjuvant Darovasertib in Primary Uveal Melanoma

This is a Phase 3, randomized, multi-center, open-label study of neoadjuvant darovasertib in subjects with primary non-metastatic uveal melanoma...

Enrolling
Uveal Melanoma
Procedure: Primary Local Therapy
Drug: Darovasertib

Phase 3

Ideaya Biosciences

Pittsburgh, Pennsylvania, United States and 93 other locations

The purpose of this study is to evaluate the effectiveness and safety of the combination of Pembrolizumab (KEYTRUDA®) and the investigational drug, M...

Enrolling
Advanced Melanoma
Drug: Metformin
Drug: Pembrolizumab Injection [Keytruda]

Phase 1

Yana Najjar

Pittsburgh, Pennsylvania, United States

alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who ...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

Phase 3

Iovance Biotherapeutics

Pittsburgh, Pennsylvania, United States and 74 other locations

therapy per local standard of care \[SoC\], best supportive care \[BSC\] on protocol survivor follow up) in patients with advanced non-ocular melanoma...

Enrolling
Advanced Melanoma
Drug: Tebentafusp with Pembrolizumab
Drug: Tebentafusp

Phase 3

Immunocore
Immunocore

Pittsburgh, Pennsylvania, United States and 81 other locations

The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the com...

Enrolling
Melanoma
Drug: fianlimab
Drug: cemiplimab

Phase 3

Regeneron Pharmaceuticals
Regeneron Pharmaceuticals

Pittsburgh, Pennsylvania, United States and 108 other locations

sub-type 1 receptor (MC1R) is being evaluated as a monotherapy and in combination with nivolumab in subjects with unresectable and metastatic melanoma...

Enrolling
Melanoma Stage IV
Melanoma Stage III
Drug: Nivolumab
Drug: [212Pb]VMT01

Phase 1, Phase 2

Perspective Therapeutics

Pittsburgh, Pennsylvania, United States and 14 other locations

This early-phase study will examine Vusolimogene Oderparepvec, a genetically modified oncolytic viral strain of the herpes simplex type 1 (HSV-1) vir...

Enrolling
Melanoma
Biological: Vusolimogene oderparepvec (RP1)

Early Phase 1

Yana Najjar

Pittsburgh, Pennsylvania, United States

positive previously untreated (1L) untreated metastatic uveal melanoma (mUM) with an integrated circulating tumor DNA (ctDNA) biomarker....

Enrolling
Uveal Melanoma
Drug: Tebentafusp

Phase 2

Diwakar Davar

Pittsburgh, Pennsylvania, United States and 2 other locations

antigen (HLA)-A\*02:01 negative participants with metastatic uveal melanoma (MUM) who will be randomized to receive either IDE196 + crizotin...

Active, not recruiting
Metastatic Uveal Melanoma
Drug: IDE196
Drug: Nivolumab

Phase 2, Phase 3

Ideaya Biosciences

Pittsburgh, Pennsylvania, United States and 67 other locations

use the immune system to recognize and kill cancer cells. The study is focused on participants with a type of skin cancer known as melanoma...

Active, not recruiting
Melanoma
Drug: Placebo
Drug: cemiplimab

Phase 2

Regeneron Pharmaceuticals
Regeneron Pharmaceuticals

Pittsburgh, Pennsylvania, United States and 103 other locations

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