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Find clinical trials for Melanoma in Sevilla, AN

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Melanoma trials near Sevilla, AN, ESP:

PLUG-IN: Pembrolizumab Combined With Enfortumab Vedotin for Advanced Melanoma Patients (PlugIN)

There is a lack of strategies for patients who progress after responding to PD-1/l-1 in melanoma. High expression of Nectin4 in skin and melanomas...

Not yet enrolling
Melanoma
Drug: enfortumab vedotin
Drug: pembrolizumab

Phase 2

Grupo Español Multidisciplinar de Melanoma

Sevilla, Spain and 12 other locations

A Randomised Phase II Study of Roginolisib in Patients with Advanced/metastatic Uveal Melanoma (OCULE-01)

The goal of this clinical trial is to learn how roginolisib works in comparison to standard treatment in adult patients with uveal/ocular melanoma...

Enrolling
Ocular Melanoma
Uveal Melanoma
Drug: roginolisib
Drug: Investigator choice of standard therapy

Phase 2

iOnctura

Seville, Spain and 15 other locations

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

alone in participants with untreated, unresectable or metastatic melanoma. Participants randomized to the pembrolizumab monotherapy arm who ...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

Phase 3

Iovance Biotherapeutics

Sevilla, Spain and 62 other locations

A Study Comparing 3 Study Medicines (Encorafenib, Binimetinib, Pembrolizumab) to 2 Study Medicines (Ipilimumab and Nivolumab) in Patients With Advanced Melanoma (PORTSIDE)

medicines (ipilimumab and nivolumab) given for the treatment of melanoma.Melanoma is a type of cancer that starts in the cells that...

Active, not recruiting
Melanoma
Drug: encorafenib
Drug: ipilimumab

Phase 2

Pfizer
Pfizer

Sevilla, Spain and 62 other locations

A Study to Evaluate Similarity of ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Resected Melanoma

(PK) similarity and efficacy, safety, and immunogenicity of ABP 206 compared with OPDIVO® (nivolumab) in subjects with resected advanced melanoma...

Active, not recruiting
Melanoma
Drug: EU-authorized Nivolumab
Drug: ABP 206

Phase 3

Amgen
Amgen

Sevilla, Andalucía, Spain and 110 other locations

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

binimetinib, and pembrolizumab) given together for the treatment of melanoma that:* is advanced or metastatic (spread to other parts of the ...

Active, not recruiting
Melanoma
Drug: Binimetinib
Drug: Encorafenib

Phase 3

Pfizer
Pfizer

Sevilla, Spain and 227 other locations

Encorafenib and biNimetinib Followed by CEmiplimab and FiAnLimab in Patients With BRAF Mutant melanOma and Symptomatic Brain Metastases (ENCEFALO)

Brain metastases in patients with advanced and metastatic melanoma are a frequent complication and a significant cause of morbidity and mort...

Begins enrollment this month
Melanoma and Brain Metastases
Melanoma BRAF V600E/K Mutated
Drug: cemiplimab+fianlimab
Drug: Encorafenib + Binimetinib

Phase 2

Grupo Español Multidisciplinar de Melanoma

Sevilla, Spain and 17 other locations

Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Brain (EBRAIN-MEL)

Phase II clinical trial, with two cohorts of patients included in parallel, all with melanoma BRAF mutated and brain metastases without prev...

Active, not recruiting
Metastatic Melanoma
Brain Metastases
Drug: binimetinib
Radiation: Whole brain radiation therapy

Phase 2

Grupo Español Multidisciplinar de Melanoma

Sevilla, Spain and 20 other locations

BO-112 With Pembrolizumab in Unresectable Malignant Melanoma (SPOTLIGHT203)

the safety of IT BO-112 in combination with intravenous (IV) pembrolizumab. The study will enroll patients with advanced and/or metastatic melanoma...

Active, not recruiting
Melanoma
Procedure: Tissue Biopsies
Drug: BO-112 plus pembrolizumab

Phase 2

Highlight Therapeutics

Sevilla, Spain and 18 other locations

Safety and Efficacy of IMCgp100 Versus Investigator Choice in Advanced Uveal Melanoma

To evaluate the overall survival of HLA-A\*0201 positive adult patients with previously untreated advanced UM receiving IMCgp100 compared to Investig...

Active, not recruiting
Uveal Melanoma
Biological: IMCgp100
Biological: Pembrolizumab

Phase 2

Immunocore
Immunocore

Sevilla, Spain and 55 other locations

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