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compared to just chemotherapy alone in participants with metastatic pancreatic cancer. One group of participants will only receive ...
Phase 2
Cincinnati, Ohio, United States and 35 other locations
is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors...
Phase 1
Cincinnati, Ohio, United States and 16 other locations
Evaluate the safety and tolerability of RMC-6236 in adults with specific RAS mutant advanced solid tumors....
Phase 1
Cincinnati, Ohio, United States and 15 other locations
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON...
Phase 1, Phase 2
Cincinnati, Ohio, United States and 13 other locations
anti-CTLA4 IgG1 monoclonal antibody, as single agent and in combination with pembrolizumab in participants with advanced or metastatic solid tumors...
Phase 1, Phase 2
Cincinnati, Ohio, United States and 36 other locations
GIT cancers. The study will be conducted in 2 parts (Part 1 and Part 2)....
Phase 1, Phase 2
Cincinnati, Ohio, United States
evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors...
Phase 1, Phase 2
Cincinnati, Ohio, United States and 219 other locations
activity of LY3962673 as monotherapy and in combination with other chemotherapy agents in participants with KRAS G12D-mutant advanced solid tumor...
Phase 1
Cincinnati, Ohio, United States and 42 other locations
pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of JANX008 in adult subjects with advanced or metastatic c...
Phase 1
Cincinnati, Ohio, United States and 12 other locations
(Hh) pathway inhibitor, in patients with refractory advanced solid tumors characterized by loss of function (LOF) mutations in the Patched-1...
Phase 2
Cincinnati, Ohio, United States and 15 other locations
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