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Find clinical trials for Pancreatic Cancer in Durham, NC

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Stomach Cancer
Cancer
Ovarian Cancer
Neoplasm Metastasis
Breast Cancer

Pancreatic Cancer trials near Durham, NC, USA:

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer

study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab in patients with metastatic KRAS G12D - mutated Pancreatic...

Enrolling
Pancreatic Ductal Adenocarcinoma (PDAC)
G12D Mutated KRAS
Drug: VS-7375
Drug: cetuximab

Phase 2

Verastem

Chapel Hill, North Carolina, United States and 28 other locations

This phase II study evaluates how well pemigatinib works for the treatment of adult patients with pancreatic cancer that has spread...

Enrolling
Metastatic Pancreatic Carcinoma
Stage IV Pancreatic Cancer AJCC v8
Drug: Pemigatinib
Procedure: Bone Scan

Phase 2

Sameek Roychowdhury

Raleigh, North Carolina, United States and 108 other locations

phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety...

Active, not recruiting
Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers
Drug: Gemcitabine
Drug: Nab-paclitaxel

Phase 1

Amgen
Amgen

Durham, North Carolina, United States and 76 other locations

1) patients with newly diagnosed, advanced, unresectable colorectal cancer (CRC) or 2) patients with newly diagnosed, advanced, unresectable ...

Enrolling
Cancer Weight Loss
Drug: TCMCB07
Drug: Placebo

Phase 2

Endevica Bio

Durham, North Carolina, United States and 25 other locations

This phase I study is designed to establish the safety, maximally tolerated dose (MTD) and recommended phase II dose (RP2D) of the ERK inhibitor ulix...

Enrolling
Pancreatic Cancer
Melanoma
Drug: Palbociclib
Drug: Ulixertinib

Phase 1

UNC Lineberger Comprehensive Cancer Center
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States of America

TNG462-C102 is a Phase 1/2, open-label, multicenter study designed to determine the safety, tolerability, PK, PD, and preliminary antineoplastic acti...

Enrolling
Pancreatic Cancer Metastatic
PDAC - Pancreatic Ductal Adenocarcinoma
Drug: TNG462
Drug: gemcitabine/nab-paclitaxel

Phase 1, Phase 2

Tango Therapeutics
Tango Therapeutics

Chapel Hill, North Carolina, United States of America and 17 other locations

The purpose of this study is to evaluate the safety and efficacy of an investigational RAS(ON) inhibitor administered as monotherapy or in combinatio...

Enrolling
Pancreatic Cancer Metastatic
Pancreatic Adenocarcinoma Metastatic
Drug: daraxonrasib
Drug: nab-paclitaxel

Phase 3

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 48 other locations

This study will help find the most suitable dose of ASP546C in people with gastric cancer, gastroesophageal junction (GEJ) cancer, ...

Enrolling
Pancreatic Adenocarcinoma
Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma
Drug: ASP546C

Phase 1, Phase 2

Astellas
Astellas

Durham, North Carolina, United States and 21 other locations

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.

Enrolling
Resected Pancreatic Adenocarcinoma
PDAC - Pancreatic Ductal Adenocarcinoma
Drug: daraxonrasib

Phase 3

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 77 other locations

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.

Active, not recruiting
PDAC - Pancreatic Ductal Adenocarcinoma
Pancreatic Cancer
Drug: 5-fluorouracil
Drug: leucovorin

Phase 3

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 59 other locations

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