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Find clinical trials for Pancreatic Cancer in Durham, NC

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Related conditions:

Adenocarcinoma
Colorectal Cancer
Cancer
Non-Small-Cell Lung Carcinoma
Lung Cancer
Carcinoma
Ovarian Cancer

Pancreatic Cancer trials near Durham, NC, USA:

A Phase II Nationwide, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

This phase II study evaluates how well pemigatinib works for the treatment of adult patients with pancreatic cancer that has spread...

Enrolling
Metastatic Pancreatic Carcinoma
Stage IV Pancreatic Cancer AJCC v8
Drug: Pemigatinib
Procedure: Bone Scan

Phase 2

Sameek Roychowdhury

Raleigh, North Carolina, United States and 70 other locations

phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety pr...

Enrolling
Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers
Drug: AMG 193
Drug: Gemcitabine

Phase 1

Amgen
Amgen

Durham, North Carolina, United States and 76 other locations

This phase I study is designed to establish the safety, maximally tolerated dose (MTD) and recommended phase II dose (RP2D) of the ERK inhibitor ulix...

Enrolling
Tumor, Solid
Pancreatic Cancer
Drug: Palbociclib
Drug: Ulixertinib

Phase 1

UNC Lineberger Comprehensive Cancer Center
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, United States of America

is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors...

Enrolling
Non-small Cell Lung Cancer (NSCLC)
Colorectal Cancer (CRC)
Drug: RMC-6236
Drug: RMC-9805

Phase 1

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 16 other locations

cancer, gastroesophageal junction cancer (GEJ cancer) or pancreatic cancer. GEJ is where the tube that ...

Enrolling
Pancreatic Adenocarcinoma
Gastroesophageal Junction (GEJ) Adenocarcinoma
Drug: Irinotecan
Drug: Leucovorin

Phase 1

Astellas
Astellas

Durham, North Carolina, United States and 42 other locations

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard(s) of care (SOC) treatment.

Enrolling
PDAC - Pancreatic Ductal Adenocarcinoma
Pancreatic Cancer
Drug: 5-fluorouracil
Drug: leucovorin

Phase 3

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 59 other locations

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON...

Enrolling
Gastrointestinal Cancer
Metastatic Pancreatic Ductal Adenocarcinoma
Drug: gemcitabine
Drug: cetuximab

Phase 1, Phase 2

Revolution Medicines
Revolution Medicines

Durham, North Carolina, United States and 29 other locations

and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers...

Active, not recruiting
Neoplasm of Lung
Neoplasms Pancreatic
Drug: Gemcitabine - 21 day cycle
Drug: 9-ING-41

Phase 2

Actuate Therapeutics

Durham, North Carolina, United States and 65 other locations

This is a Phase 1, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with adv...

Enrolling
Solid Tumor
Malignant Peripheral Nerve Sheath Tumors
Drug: MRTX1719

Phase 1

Bristol-Myers Squibb (BMS)
Bristol-Myers Squibb (BMS)

Chapel Hill, North Carolina, United States and 22 other locations

This trial will study tisotumab vedotin to find out whether it is an effective treatment alone or with other anticancer drugs for certain solid tumors...

Active, not recruiting
Exocrine Pancreatic Cancer
Colorectal Neoplasms
Drug: cisplatin
Drug: carboplatin

Phase 2

Seagen, a wholly owned subsidiary of Pfizer

Durham, North Carolina, United States and 155 other locations

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