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Intrepid Research | Cincinnati, OH

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Top conditions

Top treatments

TAK-861
JZP-258
Pitolisant
Lemborexant
Mazindol
TAK-994
AD504
Atomoxetine
Lorundrostat
High-Sodium Oxybate

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Active trials

11 of 35 total trials

A Long-Term Safety and Effectiveness Study to Evaluate Pitolisant in Adult Patients with Idiopathic Hypersomnia

The primary objective of this study is to assess the long-term safety and effectiveness of pitolisant in patients with idiopathic hypersomnia (IH) wh...

Active, not recruiting
Idiopathic Hypersomnia
Excessive Daytime Sleepiness
Drug: Pitolisant

A Phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat an aldosterone synthase inhibitor (ASI), administered as an add-on to...

Active, not recruiting
Hypertension
Drug: Placebo
Drug: lorundrostat Dose 2

The purpose of this study is to is to evaluate the efficacy and safety of retatrutide in participants with type 2 diabetes in participants who have o...

Active, not recruiting
Overweight
Obesity
Drug: Placebo
Drug: Retatrutide

The main aim is to evaluate the safety and tolerability of TAK-861 on participants with type 1 narcolepsy, who were exposed to previously tested dose...

Enrolling
Narcolepsy Type 1
Drug: TAK-861

The primary purpose of this study is to evaluate the efficacy of single oral doses of E2086 compared to placebo in the treatment of excessive daytime...

Enrolling
Narcolepsy Type 1 (NT1)
Drug: Active Comparator Placebo
Drug: E2086 Placebo

This study will assess the safety and efficacy of JZP258 (XYWAV) on sleepiness, polysomnography, and functional outcomes in patients with idiopathic...

Active, not recruiting
Idiopathic Hypersomnia
Narcolepsy
Drug: JZP258 (XYWAV)

The aim of this study is to quantify the change in blood pressure when participants with narcolepsy treated with high-sodium oxybate are transitioned...

Enrolling
Narcolepsy
Drug: JZP258
Locations recently updated

The combination drug composed of aroxybutynin and atomoxetine, designated AD109, is being developed by Apnimed for the treatment of obstructive sleep...

Invitation-only
OSA
Drug: Aroxybutynin and Atomoxetine

This study intends to examine the utility of a home-use EEG-based sleep monitor for the diagnosis and evaluation of disorders of excessive sleepiness...

Enrolling
Sleep Disorder
Narcolepsy Type 1
Device: Dreem 3S recording
Locations recently updated

This study is to evaluate the long-term safety, efficacy and tolerability of lorundrostat (an aldosterone synthase inhibitor) in subjects with hypert...

Invitation-only
Hypertension
Drug: lorundrostat
Drug: Placebo

The goal of this randomised, double-blind phase II/III clinical trial is to determine the safety and efficacy of IHL-42X in subjects with obstructive...

Enrolling
Obstructive Sleep Apnea
Drug: Acetazolamide
Drug: IHL-42X Low Dose

Trial sponsors

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