Clinical Trials of Texas | San Antonio, TX

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5430 Fredericksburg Road, Suite 200, San Antonio, Texas, United States of America

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Top conditions

Top treatments

Dasotraline

Metformin

Elagolix

Tirzepatide

PF-06865571

PF-05221304

LY3298176

Relamorelin

Rapastinel

Insulin icodec

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Active trials

38 of 292 total trials

A Clinical Trial to Evaluate the Safety, Efficacy and Immune Responses After Vaccination with an Investigational RNA-based Vaccine Against Malaria

This is a randomized, dose-escalation Phase I/IIa trial to evaluate safety, tolerability, immunogenicity and efficacy of an investigational RNA-based...

Active, not recruiting

Malaria

Biological: BNT165e

Other: Placebo

A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes (FOCUS)

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The...

Active, not recruiting

Diabetes Mellitus, Type 2

Drug: Semaglutide

Drug: Placebo (semaglutide)

A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Nonalcoholic Fatty Liver Disease

The main purpose of this study is to evaluate the safety and tolerability of the study drug LY3849891 in participants with nonalcoholic fatty liver d...

Enrolling

Non-Alcoholic Fatty Liver Disease

Drug: Placebo

Drug: LY3849891

A Study About Modified RNA Vaccines Against Influenza in Healthy Adults

The purpose of this study is to learn if modified RNA (modRNA) vaccines for the prevention of influenza are:* safe; and* how these vaccines produce a...

Active, not recruiting

Influenza, Human

Biological: Influenza ModRNA Vaccine

Biological: Quadrivalent Influenza Vaccine (QIV)

A Study in Patients with Mixed Dyslipidemia

A Phase 2 in Patients With Mixed Dyslipidemia

Enrolling

Mixed Dyslipidemia

Drug: BW-00112

A Study of Baricitinib (LY3009104) in Participants With Rheumatoid Arthritis (RA-BRIDGE)

This post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous throm...

Active, not recruiting

Rheumatoid Arthritis

Drug: Baricitinib

Drug: TNF Inhibitor

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk (ACHIEVE-4)

The main purpose of this study is to determine safety and efficacy of orforglipron compared with insulin glargine in participants with type 2 diabete...

Active, not recruiting

Chronic Kidney Disease

Overweight

Drug: Orforglipron

Drug: Insulin Glargine

A Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids

The goal of this study is to evaluate the efficacy, safety, and tolerability of enlicitide decanoate in adult participants with hypercholesterolemia....

Active, not recruiting

Hypercholesterolemia

Familial Hypercholesterolemia

Drug: Enlicitide Decanoate

Drug: Placebo

A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease (Reτain)

The purpose of this study is to assess the effect of JNJ-64042056 on cognitive decline, as measured by Preclinical Alzheimer's disease Cognitive Comp...

Enrolling

Preclinical Alzheimer's Disease

Drug: JNJ-64042056

Drug: Placebo

A Study of Mevidalen (LY3154207) in Participants With Alzheimer's Disease

The main purpose of this study is to look at how safe the study drug (mevidalen) is and whether it works to alleviate symptoms when given to people w...

Enrolling

Alzheimer Disease

Drug: Placebo

Drug: Mevidalen

A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19 (NextCOVE)

The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-...

Active, not recruiting

COVID-19

Biological: mRNA-1283.222

Biological: mRNA-1273.815

A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee (TRIUMPH-4)

The main purpose of this study is to evaluate the safety and efficacy of retatrutide once-weekly in participants who have obesity or are overweight a...

Active, not recruiting

Overweight

Obesity

Drug: Retatrutide

Drug: Placebo

A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity (SURMOUNT-MMO)

This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additiona...

Active, not recruiting

Overweight

Obesity

Drug: Placebo

Drug: Tirzepatide

A Study to Assess Safety of ABBV-916 and How Intravenous ABBV-916 Moves Through Body and Affects Brain Amyloid Plaque Clearance in Adult Participants (Aged 50-90 Years) With Early Alzheimer's Disease

Alzheimer's disease (AD) is a progressive, irreversible neurological disorder and is the most common cause of dementia in the elderly population. Cli...

Active, not recruiting

Alzheimer's Disease (AD)

Drug: Placebo

Drug: ABBV-916

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

The purpose of this study is to evaluate the efficacy of lepodisiran in reducing cardiovascular risk in participants with high lipoprotein(a) who hav...

Enrolling

Atherosclerotic Cardiovascular Disease (ASCVD)

Elevated Lp(a)

Drug: Lepodisiran Sodium

Drug: Placebo

A Study to Learn About a Modified RNA Vaccine Against Shingles in Healthy Adults

The purpose of this clinical study is to learn about the safety, extent of the side effects (reaction to vaccine), and immune response (your immune s...

Active, not recruiting

Shingles

Human

Biological: Selected Vaccine Candidate group (Dose level, Schedule)

Biological: Shingrix - SSB

A Study to Learn About the Safety and Immune Response of a New Pneumococcal Vaccine in Adults

The purpose of this study is to learn about the safety and immune effects of a pneumococcal vaccine in adults. This vaccine can possibly provide prot...

Active, not recruiting

Pneumococcal Disease

Biological: 20-valent pneumococcal conjugate vaccine (20vPnC)

Biological: Multivalent Pneumococcal Vaccine - Formulation 2

A Study to Test Whether Survodutide Helps People Living With Obesity or Overweight and With a Confirmed or Presumed Liver Disease Called Non-alcoholic Steatohepatitis (NASH) to Reduce Liver Fat and to Lose Weight

This study is open to adults who are at least 18 years old and have* presumed or confirmed NASH together with overweight or obesity and* a body mass...

Enrolling

Non-Alcoholic SteatoHepatitis (NASH)

Obesity

Drug: Survodutide

Drug: Placebo

A Trial to Investigate the Non-inferiority of Pegloticase Administered Every 4 Weeks (Q4W) With MTX Compared With Every 2 Weeks (Q2W) With MTX in Participants With Uncontrolled Refractory Gout

The study consists of 24-week double-blind trial to evaluate the non-inferiority of the efficacy and safety of pegloticase Q4W with MTX versus peglot...

Enrolling

Gout

Drug: Methotrexate

Biological: Pegloticase

Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus

The study aims to compare and assess the dose response of 3 selected doses of maridebart cafraglutide compared with placebo, on inducing and maintain...

Active, not recruiting

Overweight

Type 2 Diabetes Mellitus

Drug: Placebo

Biological: Maridebart Cafraglutide