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Active trials

19 of 38 total trials

A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL) (EPCORE DLBCL-1)

The purpose of this trial is to find out if epcoritamab, also known as EPKINLY™ and GEN3013, is safe and works well as treatment for participants wit...

Active, not recruiting
Diffuse Large B-cell Lymphoma
Drug: Investigator's Choice Chemotherapy
Biological: Epcoritamab

This is a Phase III, two-arm, randomized, double-blind placebo-controlled study in participants with HER2-positive primary breast cancer who have rec...

Active, not recruiting
Breast Cancer
Drug: Trastuzumab Emtansine
Drug: Placebo

This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with phy...

Active, not recruiting
Early Breast Cancer
Drug: Giredestrant
Drug: LHRH Agonist

This is a Phase III, multicenter, randomized, open-label, global study designed to evaluate the efficacy and safety of inavolisib plus fulvestrant co...

Active, not recruiting
Breast Cancer
Drug: Alpelisib
Drug: Fulvestrant

This study will evaluate the efficacy and safety of mosunetuzumab in combination with lenalidomide (M + Len) compared to rituximab in combination wit...

Active, not recruiting
Relapsed or Refractory Follicular Lymphoma
Drug: Lenalidomide
Drug: Rituximab

This is a Phase 3, randomized, multinational, double-blind, dual placebo-controlled, 4-arm study evaluating rucaparib and nivolumab as maintenance tr...

Active, not recruiting
FIGO Stage III-IV
Newly Diagnosed
Drug: Placebo Oral Tablet
Drug: Nivolumab

This is a Phase 1b/2 study to investigate the efficacy and safety of alcestobart (LBL-007) plus tislelizumab when administered in combination with be...

Active, not recruiting
Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer
Drug: Alcestobart
Drug: Bevacizumab or Bevacizumab biosimilar

This phase 3 randomized, open-label multicenter trial will compare the efficacy, safety and the impact on health-related quality of life (HR-QoL) of...

Active, not recruiting
Multiple Myeloma
Drug: Selinexor
Drug: Elotuzumab

The primary goal of this study is to evaluate the effectiveness of elacestrant versus standard endocrine therapy in participants with node-positive,...

Enrolling
Breast Cancer
Drug: Elacestrant
Drug: Tamoxifen

The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cance...

Active, not recruiting
Breast Neoplasms
Drug: Anastrozole
Drug: Tamoxifen

Ovarian cancer is a lethal disease with an estimated 310,000 new cases and 200,000 deaths experienced worldwide in 2020. The purpose of this study is...

Enrolling
Ovarian Cancer
Drug: Bevacizumab
Drug: Mirvetuximab Soravtansine

The primary objectives of the study are: (1) in the dose-escalation part: to evaluate safety and tolerability and to determine the recommended Phase...

Enrolling
Solid Tumor
Drug: Lenvatinib
Drug: Farletuzumab ecteribulin

The purpose of this study is to compare any good and bad effects of using radium-223 along with docetaxel chemotherapy treatment versus using docetax...

Active, not recruiting
Prostate Cancer
Drug: Radium-223
Drug: Docetaxel 60 mg/m2

IMGN853-0420 is a multicenter, open-label, phase 2 study of carboplatin plus mirvetuximab soravtansine followed by mirvetuximab soravtansine continua...

Active, not recruiting
Primary Peritoneal Cancer
High Grade Ovarian Cancer
Drug: Mirvetuximab soravtansine
Drug: Carboplatin

TIVDAK is used for the treatment of cervical cancer that has come back after chemotherapy. Chemotherapy is a treatment that uses medicines to stop th...

Enrolling
Cervical Cancer
Drug: TIVDAK
Locations recently updated

The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib...

Enrolling
Early Breast Cancer
Drug: Goserelin
Drug: Ansastrozole

The purpose of this study is to assess the efficacy and safety of belzutifan (MK-6482) plus fulvestrant compared to everolimus plus endocrine therapy...

Active, not recruiting
Metastatic Breast Cancer
Drug: Belzutifan
Drug: Fulvestrant

This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combinatio...

Enrolling
Melanoma
Unresectable Melanoma
Biological: Pembrolizumab with Optional Crossover Period
Biological: Lifileucel plus Pembrolizumab

This is a randomized, controlled, multicenter, open-label Phase 3 clinical study comparing VO in combination with nivolumab versus Physician's Choice...

Enrolling
Advanced Melanoma
Biological: Vusolimogene Oderparepvec
Biological: Nivolumab

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