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Evolution Research Group | Clinical Pharmacology of Miami

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CTP-543
SSP-004184
Risankizumab
SPD602
LY3502970
Isavuconazole
Quizartinib
BMS-986177
BMS-820132
Tirzepatide

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Active trials

14 of 202 total trials

A Bioequivalence Study of Amlitelimab Delivered by 2 Different Devices in Healthy Adult Participants

This is a single-center, open-label, randomized, single-dose, parallel, Phase 1, 4-arm study designed to determine the bioequivalence and investigate...

Active, not recruiting
Healthy Volunteers
Combination Product: SAR445229

The principal aim of this study is to obtain safety and tolerability data when MRT-8102 is administered orally as single and multiple doses to health...

Enrolling
Healthy Volunteers
Elevated CRP
Drug: Placebo
Drug: MRT-8102

The main purpose of this study is to evaluate how much lepodisiran gets into the blood stream and how long it takes the body to get rid of it when gi...

Enrolling
Healthy
Liver Dysfunction
Drug: Lepodisiran

This is a 4-part study that includes a Part A, Part B, Part C, and Part D. Parts A and D will study the safety and tolerability of the study drug kno...

Active, not recruiting
Overweight
Obesity
Drug: Placebo
Drug: LY3537031

The purpose of this study is to compare the plasma pharmacokinetics (PK) of nemabrutinib (MK-1026) following a single oral dose of nemtabrutinib in p...

Enrolling
Hepatic Impairment (HI)
Drug: Nemtabrutinib

This is a Phase 3, randomized, double-blind, comparator- and placebo-controlled study to evaluate analgesic efficacy and safety of TLC590 via local i...

Enrolling
Postoperative Pain
Drug: Saline Placebo
Drug: Liposomal Bupivacaine

This study is to assess how oral emraclidine moves through the body of healthy elderly adult participants, and assess adverse events, and tolerabilit...

Enrolling
Healthy Volunteer
Drug: Emraclidine
Drug: Placebo

Researchers have designed a study medicine called opevesostat as a new way to treat prostate cancer.The purpose of this study is to learn what happen...

Active, not recruiting
Hepatic Impairment
Healthy Participants
Drug: Fludrocortisone acetate
Drug: Opevesostat

The main objective of this trial is to evaluate the pharmacokinetics (PK) of maridebart cafraglutide administered as a single dose using two differen...

Enrolling
Overweight and Obesity
Drug: Maridebart Cafraglutide

This study will evaluate and compare the PK in subjects with severe HI to that of matched healthy control subjects with normal hepatic function.

Enrolling
Hepatic Impairment
Drug: Quizartinib

The main purpose of this study is to compare the bioavailability of 3 different formulations of LY4100511 and if the use of a proton pump inhibitor (...

Enrolling
Healthy Participants
Drug: Rabeprazole
Drug: LY4100511

The purposes of this study are to determine:* The pharmacokinetics (the amount of study drug in your blood and how long it takes the body to get rid...

Enrolling
Hepatic Impairment
Healthy
Drug: Mirdametinib (MEK Inhibitor)

This is a First in Human study to evaluate the safety and tolerability of DA-1726 following single and multiple doses in participants with obesity, b...

Enrolling
Obesity
Drug: Placebo to DA-1726
Drug: DA-1726

The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.

Enrolling
Cardiometabolic Disease
Drug: Placebo
Drug: AMG 513

Trial sponsors

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