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Evolution Research Group | Clinical Pharmacology of Miami

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CTP-543
SSP-004184
Risankizumab
Isavuconazole
LY3502970
SPD602
Quizartinib
BMS-986177
BMS-820132
Tirzepatide

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Active trials

15 of 192 total trials

A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy

The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of VX-993 in treating acute pain after a bunionectom...

Enrolling
Acute Pain
Drug: VX-993
Drug: Placebo (matched to HB/APAP)

The main purpose of this study is to evaluate how much lepodisiran gets into the blood stream and how long it takes the body to get rid of it when gi...

Not yet enrolling
Healthy
Liver Dysfunction
Drug: Lepodisiran

This is a 3-part study that includes a Part A, Part B, and Part C. Part A will study the safety and tolerability of the study drug known as LY3537031...

Enrolling
Healthy
Obesity
Drug: LY3537031
Drug: Placebo

The purpose of the study is to learn about the safety of MK-2225, including how well people tolerate it. Researchers also want to learn what happens...

Active, not recruiting
Systemic Sclerosis
Drug: MK-2225
Other: Placebo

The purpose of this study is to compare the plasma pharmacokinetics (PK) of nemabrutinib (MK-1026) following a single oral dose of nemtabrutinib in p...

Enrolling
Hepatic Impairment (HI)
Drug: Nemtabrutinib

The main purpose of this study is to assess how olomorasib gets into the blood stream and how long it takes the body to remove it when administered t...

Enrolling
Healthy
Hepatic Insufficiency
Drug: Olomorasib

The main purpose of this study is to see how orforglipron affects the amount of body fat compared with placebo in participants with obesity or overwe...

Active, not recruiting
Overweight
Obesity
Drug: Orforglipron
Drug: Placebo

The purpose of this study is to assess the effect of severe renal impairment (RI) and end-stage renal disease (ESRD) with intermittent hemodialysis (...

Enrolling
Renal Impairment
Healthy Volunteers
Drug: BMS-986278

Researchers have designed a study medicine called opevesostat as a new way to treat prostate cancer.The purpose of this study is to learn what happen...

Enrolling
Hepatic Impairment
Healthy Participants
Drug: Fludrocortisone acetate
Drug: Opevesostat

This study will evaluate and compare the PK in subjects with severe HI to that of matched healthy control subjects with normal hepatic function.

Enrolling
Hepatic Impairment
Drug: Quizartinib

The main purpose of this study is to compare the bioavailability of 3 different formulations of LY4100511 and if the use of a proton pump inhibitor (...

Enrolling
Healthy Participants
Drug: Rabeprazole
Drug: LY4100511

This is a First in Human study to evaluate the safety and tolerability of DA-1726 following single and multiple doses in participants with obesity, b...

Enrolling
Obesity
Drug: Placebo to DA-1726
Drug: DA-1726

A phase 2b, multicenter, randomized, double-blind, placebo-controlled study of HTD1801 in adult subjects with non-alcoholic steatohepatitis and liver...

Active, not recruiting
Nonalcoholic Steatohepatitis (NASH)
Type 2 Diabetes
Drug: Placebo
Drug: HTD1801

The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.

Enrolling
Cardiometabolic Disease
Drug: Placebo
Drug: AMG 513

The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilater...

Enrolling
Total Knee Arthroplasty (Postoperative Pain)
Drug: ATX101
Drug: bupivacaine hydrochloride

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