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IUCT Oncopole | Institut Claudius Regaud - Plateforme investigation clinique

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Azacitidine
Venetoclax
Cyclophosphamide
Doxorubicin
EPREX
Pregabalin
Golcadomide
Inavolisib
Capsaicin
Atezolizumab

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Active trials

14 of 41 total trials

A Phase 1 Study With ABBV-CLS-484 in Subjects With Locally Advanced or Metastatic Tumors

The study will assess the safety, PK, PD, and preliminary efficacy of ABBV-CLS-484 as monotherapy and in combination with a PD-1 targeting agent or w...

Enrolling
Advanced Solid Tumor Cancer
Drug: Vascular Endothelial Growth Factor Receptor (VEGFR) Tyrosine Kinase Inhibitor (TKI)
Drug: ABBV-CLS-484

This is a Phase III, multicenter, randomized, open-label, global study designed to evaluate the efficacy and safety of inavolisib plus fulvestrant co...

Enrolling
Breast Cancer
Drug: Alpelisib
Drug: Inavolisib

This is an open-label, multicenter, extension study. Patients who are receiving clinical benefit from atezolizumab monotherapy or atezolizumab in com...

Enrolling
Cancer
Drug: Emactuzumab
Drug: Niraparib

The purpose of this study is to evaluate the safety and tolerability of CFT1946 as well as to determine the maximum tolerated dose (MTD) and/or the r...

Enrolling
ATC
Melanoma
Drug: Trametinib
Drug: Cetuximab

This is a Phase III, randomized, open-label multicenter study that will evaluate the efficacy and safety of giredestrant compared with fulvestrant, b...

Enrolling
Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer
Diagnostic Test: FoundationOne Liquid CDx Assay (F1LCDx)
Drug: Giredestrant

This is a Phase III, international, multicentre, randomised, double-blinded placebo controlled trial, evaluating the efficacy and safety of ADT +/- d...

Enrolling
Prostate Cancer Metastatic
Drug: Androgen deprivation therapy
Drug: Darolutamide 300 mg

The purpose of this study is to compare the efficacy and safety of glofitamab in combination with polatuzumab vedotin plus rituximab, cyclophosphamid...

Enrolling
Large B-Cell Lymphoma
Drug: Rituximab
Drug: Glofitamab

Open-label phase II, single arm, multicenter study with safety run-in to evaluate the efficacy and safety of Azacitidine combined with Venetoclax in...

Enrolling
Chronic Myeloid Leukemia
Drug: Venetoclax

This study encompasses two multicenter, prospective, open-labeled, 2-arm, non-comparative randomized phase II trials to assess the antitumor activity...

Enrolling
Metastatic Soft-tissue Sarcoma
Advanced Soft-tissue Sarcoma
Drug: Bintrafusp alfa
Drug: Doxorubicin

Phase II trial with three independent strata to independently assess the effects of the association of pembrolizumab and cabozantinib in advanced sar...

Enrolling
Osteosarcoma
Soft Tissue Sarcoma Adult
Drug: Association of pembrolizumab + cabozantinib

This phase I/II open-label, dose-finding, multi-center study will assess safety and primary efficacy of Onureg and Venetoclax combination, to define...

Enrolling
Untreated Myelodysplastic Syndrome
Drug: Onureg + Venetoclax

PEACE-6 Poor Responders is an international, multicenter, open-label, controlled, randomized, phase III trial to evaluate the efficacy and safety of...

Enrolling
Prostate Cancer Metastatic
Drug: 177Lu-PMSA-617
Drug: Standard of Care

The purpose of this study is to evaluate the safety, tolerability, and preliminary activity of MP0533 in patients with relapsed/refractory acute myel...

Enrolling
Acute
Relapsed
Drug: MP0533 (multispecific DARPin CD3 Engager Targeting CD33, CD123 and CD70)

Study to assess venetoclax + azacitidine and donor lymphocyte infusion (DLI) in patients with myelodysplastic syndrome (MDS) or acute myeloid leukemi...

Enrolling
AML
MDS
Drug: venetoclax + azacitidine +/- donor lymphocyte infusion

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