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Active trials

19 of 44 total trials

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll...

Metastatic Cancer
Advanced Gastrointestinal Stromal Tumors
Drug: CGT9486
Drug: Sunitinib

This is a Phase 1 study to assess the safety and clinical activity of RO7623066 alone and in combination in patients with advanced solid tumors.

Advanced Solid Tumors
Drug: RO7623066
Drug: Olaparib

This study will evaluate the efficacy and safety of multiple therapies in participants with locally advanced, unresectable, Stage III NSCLC with elig...

Non-Small Cell Lung Cancer
Drug: Durvalumab
Drug: Entrectinib

This is an open-label, multicenter, extension study. Patients who are receiving clinical benefit from atezolizumab monotherapy or atezolizumab in com...

Drug: Emactuzumab
Drug: Niraparib

This phase 1 study will investigate the safety, tolerability, pharmacokinetic, pharmacodynamic, and clinical activity of AZD0486, a CD19 x CD3 T-cell...

B-cell Non Hodgkin Lymphoma
Follicular Lymphoma
Drug: AZD0486 IV

A Phase Ib/II, open label, multi-center, randomized study designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor ac...

Active, not recruiting
Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma
Drug: Linagliptin
Drug: Cobimetinib

Phase 1 will evaluate the safety and tolerability at different dose levels of repotrectinib in pediatric and young adult subjects with advanced or me...

Locally Advanced Solid Tumors
Primary CNS Tumors
Drug: Oral repotrectinib (TPX-0005)

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary anti-tumor activity o...

Small Cell Lung Cancer
Neuroendocrine Carcinoma
Drug: Tocilizumab
Drug: RO7616789

This is a phase I/II, open-label, dose-escalation study designed to evaluate the safety, tolerability, and efficacy of RO7227166 in participants with...

Lymphoma, Non-Hodgkin
Drug: Obinutuzumab
Drug: RO7227166

This is an open-label, multicenter, non-randomized, Phase 2 study to determine the safety, tolerability and efficacy of encorafenib given in combinat...

Active, not recruiting
Non-small Cell Lung Cancer
Drug: encorafenib
Drug: binimetinib

This is an open-label, multi-center Phase 1b clinical study of oral AS-1763 in patients with CLL/SLL or B-cell NHL who have failed or are intolerant...

Waldenstrom Macroglobulinemia
Marginal Zone Lymphoma
Drug: AS-1763

This study is open to people with a type of cancer called dedifferentiated liposarcoma. People with advanced liposarcoma aged 18 or older who are not...

Active, not recruiting
Liposarcoma, Dedifferentiated
Drug: Brigimadlin (BI 907828)
Drug: Doxorubicin

This is a phase I, multicenter, open-label, dose-escalation study of cevostamab administered as a single agent by IV infusion to participants with re...

Multiple Myeloma
Drug: Cevostamab
Drug: Tocilizumab

A Phase 1a/1b, multicenter, open-label, non-randomized, dose-escalation, and cohort expansion study to examine the DLTs, MTD, and RP2D of SB 11285 ad...

Solid Tumor
Drug: Atezolizumab
Drug: SB 11285

The study objective is to determine the biomarker status of a participant's tumor tissue and use that status to determine eligibility for a linked Ro...

Solid Tumors
Other: Screening platform

A Phase Ib/II, open-label, multicenter, randomized, umbrella study in participants with MIBC and in participants with locally advanced or metastatic...

Bladder Cancer
Urothelial Carcinoma
Drug: Enfortumab Vedotin
Drug: Tiragolumab

Iadademstat is being studied as a treatment for subjects with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML) with FMS-like tyrosine kinase m...

Acute Myeloid Leukemia Refractory
Acute Myeloid Leukemia, in Relapse
Drug: Gilteritinib Oral Tablet
Drug: Iadademstat

This study is a Phase III, Randomized, Controlled, Global Multicenter Study to Evaluate the Efficacy and Safety of Oral Tinengotinib versus Physician...

Drug: Physician's Choice
Drug: Tinengotinib 8 mg

TAPISTRY is a Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or imm...

Solid Tumors
Drug: Atezolizumab
Drug: Trastuzumab emtansine

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