The University of Texas MD Anderson Cancer Center | Texas Medical Center - Lymphoma and Myeloma Department

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1515 Holcolmbe Blvd, Houston, Texas, United States of America
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Lymphoma (52 trials)

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187 of 412
Status: Active
Trial type: Interventional
Funder type: Industry

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), includ...

SM With an Associated Hematologic Neoplasm (SM-AHN)
Aggressive Systemic Mastocytosis (ASM)
Drug: bezuclastinib

This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll...

Metastatic Cancer
Advanced Gastrointestinal Stromal Tumors
Drug: CGT9486
Drug: Sunitinib

This is a multi-part, randomized, double-blind, placebo-controlled Phase 2 clinical study comparing the safety and efficacy of bezuclastinib (CGT9486...

Mastocytosis, Systemic
Drug: Bezuclastinib Tablets (Formulation A)
Drug: Placebo Tablets

This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (P...

Active, not recruiting
Neoplasms, Nerve Tissue
Drug: osimertinib
Drug: BLU-945

This is a Phase 1/2 study to investigate the safety and efficacy of the CAR-T therapy, ONCT-808, in patients with relapsed/refractory (R/R) aggressiv...

Relapsed/Refractory Aggressive B-Cell Malignancies
Drug: Bridging Therapy
Biological: ONCT-808

The goal of this clinical research study is to determine whether it is safe and practical to give CK0801 (a Cord blood-derived T-regulatory cell prod...

Active, not recruiting
Bone Marrow Disease
Biological: CK0801

The purpose of this clinical trial is to learn how the experimental medicine maplirpacept (PF-07901801) affects people with various types of blood ca...

Active, not recruiting
Multiple Myeloma
Drug: Dexamethasone
Drug: Venetoclax

Part 1: Dose Escalation. The primary objective of Part 1 of this study is to evaluate the safety and tolerability of KB-0742 in participants with rel...

Relapsed Solid Tumors
Refractory Solid Tumors
Drug: KB-0742

INCLINE-101 is an open label, multicenter Phase 1/2 study designed to evaluate safety, pharmacokinetics (PK), and preliminary anti-tumor activity of...

Advanced or Metastatic Solid Tumors
Drug: TAC-001

To evaluate the safety and tolerability of escalating doses of ERAS-601 when administered as a monotherapy and in combination with other cancer thera...

Active, not recruiting
Advanced or Metastatic Solid Tumors
Drug: Pembrolizumab
Drug: ERAS-601

This is an open-label, dose escalation and dose expansion study of MDK-703 as a monotherapy and in combination with other cancer therapies in adult s...

Active, not recruiting
Advanced or Metastatic Solid Tumors
Drug: Checkpoint Inhibitor, Immune
Drug: MDK-703

The study is being conducted to evaluate the safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of 3HP-2827 in the treatment of u...

Begins enrollment in 1 month
Solid Tumors With FGFR2 Alterations, Adult
Drug: 3HP-2827

A first-in-human study using BDC-1001 as a single agent and in combination with nivolumab in HER2 expressing advanced malignancies

HER2-positive Endometrial Cancer
HER2-positive Colorectal Cancer
Drug: BDC-1001
Drug: Nivolumab

The purpose of this dose escalation study is to evaluate the safety profile of escalating doses and dose schedules of NXP900.

Advanced Solid Tumor
Drug: NXP900

This is a Phase 1 dose-escalation and expansion study that will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and p...

Solid Tumor
Drug: SAIL66
Drug: Tocilizumab

This is a First in Human (FIH) Phase I/II, multinational, multicenter, open-label study of HB-201 single vector therapy and HB-201 & HB-202 two-vecto...

HPV-Related Squamous Cell Carcinoma
Drug: HB-202 intravenous administration alternating with HB-201 intravenous administration.
Drug: HB-201 intravenous administration + standard of care regimen including pembrolizumab.

This clinical trial is an interventional, active-treatment, open-label, multi-center, Phase 1/2 study. The study objectives are to assess the safety,...

Active, not recruiting
Breast Cancer
Non-hodgkin Lymphoma
Drug: CYT-0851
Drug: CYT-0851 in combination with capecitabine

This is a Phase 1/2, multicenter, open label, first in human (FIH) study of DCC-3116 as monotherapy, and in combination with trametinib, binimetinib,...

Advanced Solid Tumor
Drug: DCC-3116
Drug: Trametinib

This is a Phase 1/2, open-label, multicenter, study evaluating the safety, tolerability, PK, PD, and anti-tumor activity of MRTX0902 alone and in com...

Solid Tumor
Advanced Solid Tumor
Drug: MRTX849
Drug: MRTX0902

The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in p...

Chronic Myeloid Leukemia
Drug: ELVN-001

Trial sponsors

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Pfizer (44 trials)

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