Dignity Health | Comprehensive Blood and Cancer Center
Status and phase
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About
The study aims to determine maximum tolerated dose (MTD) or recommended combination dose of the MTA-cooperative PRMT5 inhibitor AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced methylthioadenosine phosphorylase (MTAP)-deleted gastrointestinal, biliary tract, or pancreatic cancers. The study also aims to determine the safety profile of AMG 193 administered in combination with other therapies in adult participants with metastatic or locally advanced MTAP-deleted gastrointestinal, biliary tract, or pancreatic cancers.
Enrollment
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Volunteers
Inclusion and exclusion criteria
Subprotocol B
Inclusion:
Exclusion:
Primary purpose
Allocation
Interventional model
Masking
188 participants in 2 patient groups
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Central trial contact
Amgen Call Center
Data sourced from clinicaltrials.gov
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