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Find clinical trials for Alzheimer's Disease in Charlotte, NC

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Related conditions:

Alzheimer Disease
Cognitive Dysfunction
Dementia
Mental Disorders
Brain Diseases
Nervous System Diseases
Neurodegenerative Diseases

Alzheimer's Disease trials near Charlotte, NC, USA:

A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)

and pharmacodynamic effects of ACI-24.060 in subjects with prodromal Alzheimer's disease and in non-demented adults with Down syndr...

Enrolling
Prodromal Alzheimer's Disease
Alzheimer's Disease
Biological: ACI-24.060 at Dose A in Study Part 1a
Biological: ACI-24.060 with an additional adjuvant at Dose D in Study Part 1b

Phase 1, Phase 2

AC Immune

Matthews, North Carolina, United States and 25 other locations

The study medicine GSK4527226 is being studied in participants with Alzheimer's Disease (AD) in study 219867 (the parent study, NCT...

Enrolling
Alzheimer's Disease
Drug: GSK4527226

Phase 2

GlaxoSmithKline (GSK)
GlaxoSmithKline (GSK)

Matthews, North Carolina, United States and 32 other locations

and efficacy of ONO-2020 in participants with mild to moderate Alzheimer's disease (AD). This study aims to determine whether admin ...

Active, not recruiting
Alzheimer Disease
Drug: Placebo
Drug: ONO-2020

Phase 2

Ono Pharmaceutical Co., Ltd.

Charlotte, North Carolina, United States of America and 82 other locations

is superior to placebo on change from baseline of the Preclinical Alzheimer Cognitive Composite 5 (PACC5) at 216 weeks of treatment (A45 Tri...

Active, not recruiting
Preclinical Alzheimer's Disease
Early Preclinical Alzheimer's Disease
Drug: Lecanemab
Drug: Placebo

Phase 3

Eisai
Eisai

Matthews, North Carolina, United States and 108 other locations

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease...

Enrolling
Alzheimer's Disease
Other: Placebo
Drug: KarXT

Phase 3

Bristol-Myers Squibb (BMS)
Bristol-Myers Squibb (BMS)

Matthews, North Carolina, United States and 117 other locations

administered once every four weeks (Q4W) in slowing cognitive and functional decline as compared to placebo in participants with early Alzheimer's...

Active, not recruiting
Alzheimer Disease
Drug: Placebo
Drug: sabirnetug

Phase 2

Acumen Pharmaceuticals

Matthews, North Carolina, United States and 72 other locations

This study will be conducted to evaluate the efficacy of lecanemab in participants with early Alzheimer's disease (EAD) by determin...

Active, not recruiting
Early Alzheimer's Disease
Drug: Lecanemab SC
Drug: Placebo

Phase 3

Eisai
Eisai

Charlotte, North Carolina, United States and 247 other locations

The aim of this study is to assess the efficacy and safety of GSK4527226 in participants with early Alzheimer's Disease (AD) (inclu...

Active, not recruiting
Alzheimer's Disease
Drug: GSK4527226
Other: Placebo

Phase 2

GlaxoSmithKline (GSK)
GlaxoSmithKline (GSK)

Matthews, North Carolina, United States and 96 other locations

safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of multiple IV infusions of PMN310 in patients with early Alzheimer's...

Active, not recruiting
Alzheimer Disease, Early Onset
Drug: Placebo
Drug: PMN310

Phase 1

ProMis Neurosciences

Matthews, North Carolina, United States and 21 other locations

The purpose of this study is to evaluate the safety and efficacy of KarXT in adult participants with mild to severe Alzheimer's Disease...

Enrolling
Alzheimer Disease
Drug: Placebo
Drug: KarXT

Phase 3

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Matthews, North Carolina, United States and 307 other locations

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