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open label, multi-center, clinical study of Chimeric Antigen Receptor T Cells (CAR-T) targeting claudin18.2 in patients with advanced gastric, pancreatic...
Phase 1, Phase 2
Toronto, Ontario, Canada and 15 other locations
to participants. Part C will use the information from Parts A and B to see if PF-08046049/SGN-BB228 is safe and if it works to treat solid tumor...
Phase 1
Toronto, Other, Canada and 21 other locations
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer age....
Phase 1, Phase 2
Toronto, Ontario, Canada and 76 other locations
to assess the safety, tolerability, PK, PD, immunogenicity and anti-tumor activity of zenocutuzumab (MCLA-128) in patients with solid tumors...
Phase 2
Toronto, Ontario, Canada and 64 other locations
This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other ...
Phase 2
Toronto, Ontario, Canada and 15 other locations
of AZD0901 as monotherapy and in combination with anti-cancer agents in participants with locally advanced unresectable or metastatic solid ...
Phase 2
Toronto, Ontario, Canada and 48 other locations
BOLD-100 is an intravenously administered sterile solution containing the ruthenium-based small molecule. BOLD-100 has been shown to preferentially d...
Phase 1, Phase 2
Toronto, Ontario, Canada and 13 other locations
biliary cancer that has spread to other organs. It is hoped that this new combination of drugs (nab-paclitaxel, gemcitabine, and cisplatin)...
Phase 2
Toronto, Ontario, Canada and 1 other location
This study is open to adults with advanced solid tumors whose previous cancer treatment was not successful. People can participate ...
Phase 1
Toronto, Canada and 13 other locations
patients with lymphoma, chronic lymphocytic leukemia, or solid tumors with liver dysfunction. Romidepsin may stop the growth of cancer...
Phase 1
Toronto, Ontario, Canada and 11 other locations
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