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Acetaminophen
Ibuprofen
VX-548
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HTX-011
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Dexmedetomidine
Propofol
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HSK3486

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Active trials

17 of 62 total trials

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

This is a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing...

Active, not recruiting
Analgesia
Drug: HTX-011
Drug: Acetaminophen
Status recently updated

The purpose of this study to evaluate the effectiveness, safety, and tolerability of SUZ as part of multimodal therapy (MMT) in treating acute postop...

Not yet enrolling
Enrolling
Acute Pain
Drug: Suzetrigine

The purpose of this study is to evaluate the efficacy, safety, tolerability and pharmacokinetics of VX-993 in treating acute pain after a bunionectom...

Enrolling
Acute Pain
Drug: VX-993
Drug: Placebo (matched to HB/APAP)

The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-...

Active, not recruiting
COVID-19
Biological: mRNA-1283.222
Biological: mRNA-1273.815

This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the...

Active, not recruiting
Knee Osteoarthritis
Biological: Amniotic Suspension Allograft
Drug: Placebo

The primary objectives of this study are to evaluate the safety and reactogenicity of mRNA-1403, and to demonstrate the efficacy of mRNA-1403 to prev...

Enrolling
Acute Gastroenteritis
Norovirus Acute Gastroenteritis
Biological: mRNA-1403
Biological: Placebo

The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of different formulations of Quadriva...

Active, not recruiting
Influenza Immunization
Biological: Quadrivalent Influenza mRNA Vaccine MRT5429
Biological: Quadrivalent Influenza mRNA Vaccine MRT5421

This is a phase IIa, randomized, double-blind, placebo-controlled, multi-center proof-of-concept (POC) study in subjects with moderate to severe Atop...

Active, not recruiting
Atopic Dermatitis
Drug: Placebo
Drug: ADX-914

The primary objective of this study is to evaluate the analgesic efficacy of DMTS, compared with placebo, in subjects following abdominoplasty.

Enrolling
Pain, Postoperative
Drug: Placebo Patch
Drug: DMTS Patch

The purpose of this study is to test the long-term safety of rimegepant in the acute treatment of migraine in children and adolescents (≥ 6 to \< 18...

Enrolling
Acute Treatment of Migraine
Drug: Rimegepant (PF-07899801)

The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in chil...

Enrolling
Pediatric Migraine
Drug: Rimegepant/BHV3000
Drug: Matching placebo

The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilater...

Enrolling
Total Knee Arthroplasty (Postoperative Pain)
Drug: ATX101
Drug: bupivacaine hydrochloride

The primary goal of this clinical trial is to learn if PIPE-791 is safe and well-tolerated in adults with chronic osteoarthritis pain (COAP) or chron...

Enrolling
Chronic Low Back Pain
Chronic Osteoarthritis Pain
Drug: PIPE-791
Drug: Placebo

The purpose of this study is to evaluate the safety and blood levels of a medicine, naltrexone, contained within an implant in healthy volunteers age...

Invitation-only
Opioid Use Disorder
Device: BIOPIN-6 Placebo Implant
Combination Product: BIOPIN-6 Active Implant with Naltrexone

The purpose of this study is to evaluate Immunogenicity and Safety of a High-Dose (HD) Influenza Vaccine (IV) in Adults 50 through 64 Years of Age.

Active, not recruiting
Influenza
Biological: High-Dose trivalent influenza vaccine (Split virion, Inactivated)
Biological: Standard-dose trivalent influenza vaccine (Split virion, Inactivated)

The purpose of the Phase 1 Part of this study is to evaluate the safety, reactogenicity, and immunogenicity of mRNA-1403 and mRNA-1405 in healthy adu...

Active, not recruiting
Norovirus Acute Gastroenteritis
Biological: Placebo
Biological: mRNA-1403

The goal of this clinical trial is to learn if LTG-001 works to treat pain after third molar removal surgery in adults. It will also learn about the...

Enrolling
Acute Pain, Postoperative
Drug: Suzetrigine
Drug: LTG-001 Mid Dose

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