Chris O'Brien Lifehouse | Clinical Trials

Research site
119-143 Missenden Road, Camperdown, New South Wales, Australia
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60 of 129
Status: Active
Trial type: Interventional
Funder type: Industry

A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1)

This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and earl...

Solid Tumor
Pleural Mesothelioma
Drug: Pembrolizumab
Drug: MDNA11

The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common res...

Drug: Irinotecan
Drug: Ramucirumab

This randomized, active-controlled, multicenter, open-label, Phase III study is designed to investigate the efficacy and safety of alectinib compared...

Active, not recruiting
Carcinoma, Non-Small-Cell Lung
Drug: Carboplatin
Drug: Cisplatin

This study is an open-label, multi-center, dose-escalation, dose expansion study in adult subjects with advanced solid tumors. The study will evaluat...

Active, not recruiting
Non-small Cell Lung Cancer
Castration-resistant Prostate Cancer
Drug: SM08502
Drug: Prednisone

This is an open-label, multicenter, non-randomized extension and long-term observational study. Participants receiving atezolizumab monotherapy or at...

Active, not recruiting
Drug: Atezolizumab
Drug: Bevacizumab

This is an open-label, multicenter, extension study. Patients who are receiving clinical benefit from atezolizumab monotherapy or atezolizumab in com...

Drug: Niraparib
Drug: Pembrolizumab

The purpose of this study is to learn whether adding abemaciclib to abiraterone plus prednisone prolongs the time before prostate cancer gets worse....

Active, not recruiting
Cytochrome P-450
Antineoplastic Agents, Hormonal
Drug: Placebo for Abemaciclib
Drug: Abemaciclib

This study is being done to see how safe and effective abemaciclib is when given together with abiraterone acetate plus prednisone in participants wi...

Active, not recruiting
Prostate Cancer
Drug: Abiraterone Acetate
Drug: Placebo

The current study is designed to evaluate the efficacy and safety of AL102 in patients with progressive desmoid tumors.

Active, not recruiting
Desmoid Tumor
Drug: AL102
Other: Placebo

This study will evaluate the efficacy of tiragolumab plus atezolizumab and carboplatin and etoposide (CE) compared with placebo plus atezolizumab and...

Active, not recruiting
Small Cell Lung Cancer
Drug: Carboplatin
Drug: Tiragolumab

This is a Phase I, Open-Label, Multi-Center, Dose Finding Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of ATG-018 (ATR...

Hematological Malignancies
Advanced Solid Tumors
Drug: ATG-018

This study aims to test the safety, tolerability, and preliminary anti-tumor activity of BGB-A3055, either alone or in combination with Tislelizumab...

Solid Tumor
Advanced Solid Tumor
Drug: BGB-A3055
Drug: Tislelizumab

The purpose of this study is to compare the efficacy, as demonstrated by progression-free survival (PFS), in participants treated with amivantamab in...

Active, not recruiting
Carcinoma, Non-Small-Cell Lung
Drug: Carboplatin
Drug: Pemetrexed

The main purpose of this study is to evaluate the efficacy of the combination of doxorubicin plus the study drug known as olaratumab versus doxorubic...

Active, not recruiting
Soft Tissue Sarcoma
Drug: Doxorubicin
Drug: Olaratumab

The purpose of this study is to learn about the effects of three study medicines (encorafenib, cetuximab, and pembrolizumab) given together for the t...

Metastatic Colorectal Cancer
Biological: Pembrolizumab
Biological: Cetuximab

The purpose of this study is to evaluate two study medicines (encorafenib plus cetuximab) taken alone or together with standard chemotherapy for the...

Drug: Cetuximab
Drug: Oxaliplatin

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer...

Active, not recruiting
Urothelial Cancer
Drug: Erdafitinib
Drug: Vinflunine

The purpose of this study is to evaluate the efficacy of erdafitinib in terms of overall response rate (ORR) in adult and pediatric participants with...

Active, not recruiting
Advanced Solid Tumor
Drug: Erdafitinib

An Open Label, Multi-Center, Dose Escalation/Expansion, Phase 1/1b Study of IMU 201 (PD1-Vaxx), a B-Cell Immunotherapy as monotherapy or in combinati...

Active, not recruiting
Large Cell Carcinoma Lung
Squamous Non-small-cell Lung Cancer
Biological: IMU-201 (administered as PD1-Vaxx) - Regimen 3
Biological: IMU-201 (administered as PD1-Vaxx) - Regimen 1

The purpose of the study is to simplify amivantamab intravenous administration and to reduce dose times, by assessing a new formulation of amivantama...

Active, not recruiting
Advanced or Metastatic Non-small Cell Lung Cancer
Drug: Lazertinib
Drug: Amivantamab Intravenous

Trial conditions

Non-Small-Cell Lung Carc... (24 trials)
Cancer (19 trials)
Lung Cancer (17 trials)
Prostatic Cancer (13 trials)
Breast Cancer (12 trials)
Carcinoma (11 trials)
Colorectal Cancer (6 trials)
Squamous Cell Carcinoma (6 trials)
Squamous Cell Carcinoma... (6 trials)
Triple Negative Breast C... (6 trials)

And 58 more

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