Hospital Clinico San Carlos | Women´s Health Institute

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C / Professor Martín Lagos, Madrid, Madrid, Spain
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99 of 340
Status: Active
Trial type: Interventional
Funder type: Industry

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll...

Metastatic Cancer
Advanced Gastrointestinal Stromal Tumors
Drug: CGT9486
Drug: Sunitinib

The primary goal of this Phase 1 study is to characterize the safety and tolerability of INCMGA00012 and establish the maximum tolerated dose (MTD) o...

Active, not recruiting
Locally Advanced Solid Tumors
Metastatic Solid Tumors
Drug: retifanlimab

This study will compare the efficacy and safety of HLX04-O administered by intravitreal injection (IVT) with ranibizumab in patients with active wAMD.

Active, not recruiting
Age Related Macular Degeneration
Drug: HLX04-O
Drug: ranibizumab

A phase 3 double blind, placebo controlled study evaluating the efficacy and safety of AL001 in participants at risk for or with frontotemporal demen...

Active, not recruiting
Frontotemporal Dementia
Drug: Open label - AL001
Drug: AL001

This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulati...

Colorectal Cancer Stage III
Colorectal Cancer Stage II
Other: Observational group (no intervention)
Drug: RO7198457 intravenous (i.v.)

The X-TOLE2 Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study that will evaluate the clinical efficacy, safety and toler...

Focal Onset Seizures
Drug: XEN1101
Drug: Placebo

This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get z...

Heart Failure
Drug: Placebo
Drug: Ziltivekimab

Please note that Phase 1/2 (HV & MAD) cohort - recruitment is completed and Phase 3 Component (THRIVE) - is actively recruiting.The investigational d...

Thyroid Eye Disease
Drug: VRDN-001 Phase 3 Cohort (THRIVE)
Drug: VRDN-001 Phase 1/2 MAD (HV and TED)

The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemoth...

Non-Small Cell Lung Cancer (NSCLC)
Drug: Sotorasib
Drug: Pembrolizumab

This is a Phase III, global, randomized, open-label, multicenter, study evaluating the efficacy and safety of adjuvant giredestrant compared with end...

Early Breast Cancer
Drug: Endocrine Therapy of Physician's Choice
Drug: Abemaciclib

This Phase III, randomized, open-label, multicenter study will evaluate the efficacy and safety of giredestrant plus everolimus compared with the phy...

Estrogen Receptor (ER)-Positive, HER2-negative, Locally Advanced or Metastatic Breast Cancer
Drug: Dexamethasone Mouth Rinse
Drug: LHRH Agonist
Locations recently updated

The main purpose of the study is to evaluate the efficacy of vixarelimab compared with placebo on lung function in participants with idiopathic pulmo...

Systemic Sclerosis With Lung Involvement
Idiopathic Pulmonary Fibrosis
Drug: Vixarelimab
Drug: Placebo

The main purpose of this study is to compare progression-free survival for women with hormone receptor positive (HR+), human epidermal growth factor...

Active, not recruiting
Breast Neoplasms
Drug: Abemaciclib
Drug: Placebo

The main purpose of this study is to measure how well abemaciclib works in participants with early breast cancer who are taking hormone therapy after...

Active, not recruiting
Breast Neoplasms
Drug: Placebo
Drug: Abemaciclib

The main purpose of this study is to evaluate the safety and efficacy of abemaciclib plus tamoxifen or abemaciclib alone in women with previously tre...

Active, not recruiting
Metastatic Breast Cancer
Drug: Tamoxifen
Drug: Abemaciclib

This clinical trial is evaluating a drug called ART0380 in participants with advanced or metastatic solid tumors. The main goals of this study are to...

Metastatic Cancer
Advanced Cancer
Drug: ART0380
Drug: Gemcitabine

The purpose of this study is to understand the safety and effects of the study medicine ARV-471 (PF-07850327) given together with palbociclib in adva...

Breast Cancer
Drug: Letrozole
Drug: ARV-471 (PF-07850327)

The purpose for this study is to determine if the study drug baricitinib is effective and safe in hospitalized pediatric participants with Coronaviru...

Corona Virus Infection
Drug: Baricitinib

Brigatinib is a medicine that binds to the surface of tumor cells in some cancers and delivers a dose of chemotherapy directly to the tumor. In this...

Active, not recruiting
ALK+ Advanced NSCLC
Drug: Brigatinib
Drug: Alectinib

The purpose of this study is to assess the efficacy and safety of barzolvolimab in adult Eosinophilic Esophagitis patients.

Eosinophilic Esophagitis
Drug: Matching Placebo
Biological: barzolvolimab

Trial sponsors

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Pfizer (26 trials)

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