Oslo University Hospital | Division of Obstetrics and Gynecology, Department of Research

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Kirkeveien 166, Oslo, Oslo, Norway
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39 of 524
Status: Active
Trial type: Interventional
Funder type: Industry

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), includ...

SM With an Associated Hematologic Neoplasm (SM-AHN)
Aggressive Systemic Mastocytosis (ASM)
Drug: bezuclastinib

This is a randomized, double-blind, placebo-controlled, Phase 2/3 study comparing the efficacy and safety of BLU-263 + best supportive care (BSC) wit...

Monoclonal Mast Cell Activation Syndrome
Indolent Systemic Mastocytosis
Drug: BLU-263
Drug: Placebo

This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll...

Metastatic Cancer
Advanced Gastrointestinal Stromal Tumors
Drug: CGT9486
Drug: Sunitinib

This is a multi-part, randomized, double-blind, placebo-controlled Phase 2 clinical study comparing the safety and efficacy of bezuclastinib (CGT9486...

Mastocytosis, Systemic
Drug: Bezuclastinib Tablets (Formulation A)
Drug: Placebo Tablets

This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes mellitus (T1D) and impaired aw...

Diabetes Mellitus, Type 1
Impaired Hypoglycemic Awareness
Biological: VX-880

This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect of abelacimab relative to dalteparin on venous thromboembol...

Pulmonary Embolism
Venous Thromboembolism
Biological: Abelacimab
Drug: Dalteparin

The purpose of this study is to evaluate the clinical and endoscopic efficacy of guselkumab in pediatric participants with Crohn's Disease (CD) at th...

Crohn's Disease
Drug: Guselkumab
Drug: Placebo

Study participants will be screened during the platform study and randomly assigned to receive mirikizumab or another intervention. The purpose of th...

Crohn's Disease
Drug: Mirikizumab

This is a 2-arm, randomized, open-label, international, multicenter study comparing the efficacy of ripretinib to sunitinib in GIST patients who prog...

Active, not recruiting
Gastrointestinal Stromal Tumors
Drug: Sunitinib
Drug: Ripretinib

This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive...

Colorectal Neoplasms
Drug: oxaliplatin
Drug: cetuximab

The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinati...

Multiple Myeloma
Drug: Trametinib
Drug: Dexamethasone
Locations recently updated

The purpose of this study is to evaluate the efficacy and safety of pemigatinib versus gemcitabine plus cisplatin chemotherapy in first-line treatmen...

Metastatic Cholangiocarcinoma
Unresectable Cholangiocarcinoma
Drug: Cisplatin
Drug: Gemcitabine

The study is a multicenter, Phase Ib/IIa, open-label, dose-escalation study to evaluate the safety and tolerability of orally administered KAND567 in...

Epithelial Ovarian Cancer
Peritoneal Cancer
Drug: KAND567
Drug: Carboplatin

The purpose of the Columbus-AD study is to evaluate the efficacy and safety of 12 months of encorafenib in combination with binimetinib in adjuvant s...

Active, not recruiting
Drug: Placebo to match Encorafenib ; Placebo to match Binimetinib
Drug: Encorafenib and Binimetinib

This is a phase III, randomized, partially blinded, multicenter trial to evaluate the efficacy and safety of atezolizumab plus bevacizumab and chemot...

Active, not recruiting
Recurrent Ovarian Carcinoma
Drug: Bevacizumab
Drug: Chemotherapy
Locations recently updated

The main objective of this study is to compare efficacy of bemarituzumab combined with oxaliplatin, leucovorin, and 5-fluorouracil (5-FU) (mFOLFOX6)...

Gastric Cancer
Gastroesophageal Junction Adenocarcinoma
Drug: Bemarituzumab
Drug: Placebo

A randomized clinical trial investigating transcatheter (TAVR) versus surgical (SAVR) aortic valve replacement in patients 75 years of age or younger...

Active, not recruiting
Ventricular Outflow Obstruction
Heart Valve Diseases
Device: Transcatheter aortic valve replacement
Device: Surgical aortic valve replacement

Background of the study: The combination of daratumumab with VRd is anticipated to further improve response rates in patients and may lead to improve...

Active, not recruiting
Multiple Myeloma
Drug: velcade
Drug: Daratumumab

The main aim is to identify and describe biomarkers in different sample types related to chemoradiation followed by durvalumab treatment for stage II...

Active, not recruiting
Non Small Cell Lung Cancer
Drug: Durvalumab Injection

The purpose of this study is to evaluate the safety and performance of the Tendyne Mitral Valve System in the treatment of severe mitral regurgitatio...

Active, not recruiting
Mitral Valve Regurgitation
Device: Tendyne Mitral Valve System

Trial conditions

Colorectal Cancer (15 trials)
Bone Fractures (13 trials)
Prostatic Cancer (13 trials)
Stroke (12 trials)
Wounds and Injuries (12 trials)
Lymphoma (11 trials)
Neoplasm Metastasis (11 trials)
Syndrome (11 trials)
Brain Injuries (9 trials)
COVID-19 (9 trials)

And 90 more

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