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University of Massachusetts | Chan Medical School - Aaron Lazare Medical Research Building - Dermatology Department

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Active trials

21 of 101 total trials

A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)

This research study is studying a drug combination as a possible treatment for endometrial cancer.The drugs involved in this study are:* mirvetuximab...

Active, not recruiting
Endometrial Cancer
Drug: Pembrolizumab
Drug: IMGN853

The SUMMIT MAX study is a prospective, randomized, controlled, interventional clinical trial to evaluate the safety and effectiveness of the Route 92...

Active, not recruiting
Acute Ischemic Stroke
Device: Route 92 Medical Reperfusion System

This is a randomized, double-blind, placebo-controlled adaptive study of the safety, tolerability, and exploratory efficacy of once-daily topical WST...

Active, not recruiting
Chemotherapy-induced Peripheral Neuropathy
Drug: WST-057 Active
Drug: Placebo

The primary objective of this study is to evaluate the long-term safety and tolerability of litifilimab in participants with active systemic lupus er...

Invitation-only
Systemic Lupus Erythematosus (SLE)
Drug: Litifilimab-matching placebo
Drug: Litifilimab

In this study, researchers will learn more about a study drug called litifilimab (BIIB059) in participants with systemic lupus erythematosus (SLE). T...

Enrolling
Lupus Erythematosus, Systemic
Drug: Placebo
Drug: Litifilimab

The purpose of this study is to compare any good and bad effects of using radium-223 along with docetaxel chemotherapy treatment versus using docetax...

Enrolling
Prostate Cancer
Drug: Radium-223
Drug: Docetaxel 60 mg/m2

This is a phase II single arm trial to determine the percentage of patients without evidence of disease progression on abemaciclib and letrozole in a...

Active, not recruiting
Endometrial Cancer
Drug: Letrozole
Drug: Abemaciclib

To evaluate safety and effectiveness of the ACURATE Transfemoral Aortic Valve System for transcatheter aortic valve replacement (TAVR) in subjects wi...

Active, not recruiting
Aortic Stenosis
Device: Medtronic CoreValve TAVR System
Device: Edwards SAPIEN 3 TAVR System

The purpose of this Phase 3 study is to evaluate the efficacy and safety of Luspatercept compared with placebo in subjects with myeloproliferative ne...

Active, not recruiting
Anemia
Myelofibrosis
Other: Placebo
Drug: ACE-536

Prospective, randomized, open-label, international, multi-center clinical study to evaluate the safety and efficacy of the AccuCinch Ventricular Rest...

Enrolling
Heart Failure with Reduced Ejection Fraction (HFrEF)
Dilated Cardiomyopathy
Device: AccuCinch Ventricular Restoration System
Drug: Guideline-Directed Medical Therapy

The purpose of this clinical trial is to assess and evaluate the safety and efficacy of the Treovance Stent-Graft with Navitel Delivery System in sub...

Active, not recruiting
Abdominal Aortic Aneurysm (AAA)
Device: Subjects who receive the Treovance stent-graft

Contrast-Induced Nephropathy (CIN) can occur when patients with pre-existing kidney problems undergo procedures that use iodinated contrast media, su...

Active, not recruiting
Contrast Induced Nephropathy
Device: RenalGuard Therapy
Drug: Standard Therapy

The purpose of this randomized clinical trial is to treat patients with small to mid-sized abdominal aortic aneurysms (AAA), maximum diameter of 3.5...

Enrolling
Abdominal Aortic Aneurysm
Drug: Nectero EAST System

This is an open-label, multi-center, non-randomized Phase 1 study to determine the safety and tolerability of NKX019 (allogeneic CAR NK cells targeti...

Enrolling
Glomerulonephritis
Lupus Nephritis
Drug: NKX019
Drug: Cyclophosphamide

The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resecti...

Enrolling
Colorectal Neoplasms
Drug: SGM-101

This is a randomized, open-label study. Patients will be screened within 28 days prior to the study drug administration. Patients will be randomly as...

Enrolling
Multiple Myeloma
Drug: GPC-100
Drug: G-CSF

The Phoenix Trial is a randomized double blind placebo controlled Phase III trial to evaluate the safety and efficacy of AMX0035 for treatment of ALS

Active, not recruiting
Amyotrophic Lateral Sclerosis
Other: Placebo
Drug: AMX0035

To evaluate repigmentation and quality of life after treatment of stable vitiligo lesions using the RECELL Device.

Active, not recruiting
Vitiligo
Device: RECELL® Autologous Cell Harvesting Device

This study will be comprised of 2 parts: 1) Part A (Multiple Ascending Dose \[MAD\]) will be conducted to evaluate the safety and tolerability of ves...

Active, not recruiting
Duchenne Muscular Dystrophy
Drug: Vesleteplirsen

The WE-TRUST study is a multi-center randomized clinical trial to assess the impact of a Direct to Angio Suite (DTAS) workflow on stroke patient outc...

Enrolling
Stroke, Acute
Procedure: Conventional CT/MR triage
Device: Direct to Angio Suite (DTAS) Philips' CBCT triage

Trial sponsors

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